Evaluation of sesamol for anxiolytic activity in 72 hours sleep deprivation model in C57BL/6 mice

Background: In our study, we explored anxiolytic activity of sesamol in C57BL/6 mice. Anxiety was induced mice after 72 hours sleep deprivation. assessed by three behavioural tests as Open field test, hole board test and light dark chamber test. Methods: evaluated for activity. flower pot technique, which deprivation done hours. After deprivation, the animals were subjected to tests, open Hole Light parameter time spent central square, that considered a measure increase number head dips indicative assessment also where more is Results: 20 mg/kg group, square statistically significant (p<0.05) post hoc comparison, suggesting exhibited effect animals. group showed indicating its said model. there diazepam compared control while not with either dose Conclusions: So, conclude,